msugita -at- infront.kyoto-u.ac.jp
dmorita -at- infront.kyoto-u.ac.jp
mizutani -at- infront.kyoto-u.ac.jp
Full attention of this laboratory has been directed to previously unappreciated aspects of the acquired immunity that we call “lipid immunity” . Unlike conventional MHC molecules that present protein-derived peptide antigens, molecules of the human group 1 CD1 family (CD1a, CD1b, CD1c) mediate presentation of “lipid” antigens to specific T lymphocytes. In addition, we have recently identified a novel lineage of antigen-presenting molecules, termed LP1, capable of mediating presentation of “lipopeptide” antigens. By taking cell biological, immunological and lipid chemical approaches, this laboratory wishes to establish a molecular and cellular basis for lipid immunity and determine how CD1 and LP1 have been evolved to function critically in host defense. An important extension of this research is a challenge for developing a new type of lipid-based vaccines against cancer and microbial infection.
Laboratory of Cell Regulation and Molecular Network Keyword
immunology host defense, biological defense lipid biochemistry lipid immunity cancer immunity infectious immunity vaccine development tuberclosis AIDS transgenic mice