shimizu -at- virus.kyoto-u.ac.jp
Major goal of research in this laboratory is to understand molecular and cellular mechanisms underlying highly systemic functions of living things, such as immune and neural systems. For this purpose, structure and regulation of genetic information responsible for such systemic functions are being analyzed using model animals, for example, transgenic or gene disrupted mice. Our research is focused on the following subjects:
- Analysis of molecular mechanisms and regulation of chromatin modification, gene expression, gene rearrangements and RNA processing during lymphocyte differentiation.
- Making and characterization of model mice of immunodeficiency or autoimmune by introduction of, or targeted disruption of interleukin, immunoglobulin or other genes.
- Analysis of molecular and cellular mechanism for lymphocyte mobility and formation of immunomicroenvironment during development and immune reaction.
Laboratory of Genetic Information Keyword
immune system antibody gene recombination class switch lymphocyte differentiation and activation immune memory transcriptional regulation cytokine IgE autoimmunity