Publication
List (1984-)
2017
Ikeda
T, Uno M, Honjoh S, Nishida E. The MYST
family histone acetyltransferase complex regulates stress resistance and
longevity through transcriptional control of DAF-16/FOXO transcription factors.
EMBO Rep. pii:
e201743907. [Epub ahead of print]
Kogure A, Uno M, Ikeda T, Nishida E. The MicroRNA Machinery Regulates Fasting-Induced Changes in Gene Expression and Longevity in Caenorhabditis elegans. J Biol Chem. 292(27):11300-11309 (2017)
Imajo M, Kondoh K, Yamamoto T,
Nakayama K, Nakajima-Koyama M, Nishida E. Antagonistic interactions between ERK
MAP kinase and retinoic acid receptor signaling in colorectal cancer cells. Mol
Cell Biol. 37 (15) pii: e00012-17 (2017)
Bansho Y, Lee J, Nishida E,
Nakajima-Koyama M. Identification and characterization of secreted factors that
are upregulated during somatic cell reprogramming. FEBS Lett. 591(11):1584-1600
(2017)
Kon S, Ishibashi K, Katoh H,
Kitamoto S, Shirai T, Tanaka S, Kajita M, Ishikawa S, Yamauchi H, Yako Y,
Kamasaki T, Matsumoto T, Watanabe H, Egami R, Sasaki A, Nishikawa A, Kameda I,
Maruyama T, Narumi R, Morita T, Sasaki Y, Enoki R, Honma S, Imamura H, Oshima
M, Soga T, Miyazaki JI, Duchen MR, Nam JM, Onodera Y, Yoshioka S, Kikuta J,
Ishii M, Imajo M, Nishida E, Fujioka Y, Ohba Y, Sato T, Fujita Y. Cell
competition with normal epithelial cells promotes apical extrusion of
transformed cells through metabolic changes. Nat Cell Biol.
19(5):530-541 (2017)
Hoshikawa H, Uno M, Honjoh S, Nishida E. Octopamine enhances oxidative stress resistance through the fasting-responsive transcription factor DAF-16/FOXO in C. elegans. Genes Cells. (2):210-219. (2017)
Ashida Y, Nakajima-Koyama M, Hirota
A, Yamamoto T, Nishida E. Activin A in combination with ERK1/2 MAPK pathway
inhibition sustains propagation of mouse embryonic stem cells. Genes
Cells. (2):189-202. (2017)
Kishimoto S, Uno M, Okabe E, Nono
M, Nishida E. Environmental stresses induce transgenerationally inheritable
survival advantages via germline-to-soma communication in Caenorhabditis elegans. Nat Commun. 8:14031 (2017)
2016
Ihara A, Uno M, Miyatake K, Honjoh
S, Nishida E. Cholesterol regulates DAF-16 nuclear localization and
fasting-induced longevity in C. elegans.
Exp
Gerontol. S0531-5565(16)30463-6 (2016).
Iimura A, Yamazaki F, Suzuki T,
Endo T, Nishida E, Kusakabe M. The E3 ubiquitin ligase Hace1 is required for
early embryonic development in Xenopus laevis. BMC Dev Biol. 16(1):31.
(2016)
Masaharu Uno and Eisuke Nishida.
Lifespan-regulating genes in C. elegans.
npj
Aging and Mechanisms of Disease. (2016) 2, 16010;
doi:10.1038/npjamd.2016.10
Kimura M, Nakajima-Koyama M, Lee J,
Nishida E. Transient Expression of WNT2 Promotes Somatic Cell Reprogramming by
Inducing β-Catenin Nuclear Accumulation. Stem Cell Reports. 6(6):834-43. (2016)
Usui M, Uno M, Nishida E. Src
family kinases suppress differentiation of brown adipocytes and browning of
white adipocytes. Genes Cells. 21(4):302-10. (2016)
2015
Ordóñez-Morán P, Dafflon C, Imajo M, Nishida E, Huelsken J. HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer. Cancer Cell. 28(6):815-29. (2015)
Nakajima-Koyama M, Lee J, Ohta S,
Yamamoto T, Nishida E. Induction of Pluripotency in
Astrocytes through a Neural Stem Cell-Like State. J
Biol Chem. 290(52):31173-88. (2015)
Lee
J, Nakajima-Koyama M, Sone M, Koga M, Ebisuya M, Yamamoto T, Nishida E. Secreted Ephrin Receptor A7 Promotes
Somatic Cell Reprogramming by Inducing ERK Activity Reduction. Stem Cell Reports. 5(4):480-9. (2015)
Miyatake K, Kusakabe M, Takahashi C, Nishida E. ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled. Nat Commun. 6:6666. (2015)
Matsuda M, Koga M, Woltjen K,
Nishida E, and Ebisuya M. Synthetic lateral inhibition governs cell-type
bifurcation with robust ratios. Nat Commun.
6:6195. (2015)
Zheng X, Suzuki T, Takahashi C,
Nishida E, and Kusakabe M. cnrip1 is a regulator of eye and neural development
in Xenopus laevis. Genes Cells.
20(4):324-39. (2015)
Takahashi C, Kusakabe M, Suzuki T,
Miyatake K, and Nishida E. mab21-l3 regulates cell fate specification
of multiciliate cells and ionocytes. Nat Commun.
6:6017 (2015)
Imajo M, Ebisuya M and Nishida E. Dual role of YAP and TAZ in renewal of the intestinal epithelium. Nat Cell Biol. 17(1):7-19. (2015)
2014
Miyata Y, Shibata T, Aoshima M,
Tsubata T and Nishida E. The Molecular Chaperone TRiC/CCT Binds to the Trp-Asp
40 (WD40) Repeat Protein WDR68 and Promotes Its Folding, Protein Kinase DYRK1A
Binding, and Nuclear Accumulation. J Biol Chem. 289(48):33320-32. (2014)
Matsumura R, Tsuchiya Y, Tokuda I,
Matsuo T, Sato M, Node K, Nishida E and Akashi M. The mammalian circadian clock
protein Period counteracts Cryptochrome in phosphorylation dynamics of
Circadian locomotor output cycles kaput (CLOCK). J
Biol Chem. 289(46):32064-72. (2014)
Adachi M, Kawasaki A, Nojima H,
Nishida E and Tsukita S. Involvement of IQGAP family proteins in the regulation
of mammalian cell cytokinesis. Genes Cells 19(11):803-20.
(2014)
Takayama M, Miyatake K and Nishida
E. Identification and characterization of retinoic acid-responsive genes in
mouse kidney development. Genes Cells. 19(8):637-49.
(2014)
Akashi M, Okamoto A, Tsuchiya Y,
Todo T, Nishida E, Node K. A positive role for PERIOD in mammalian circadian
gene expression. Cell Rep. 7(4):1056-64. (2014)
Sunadome K., Suzuki T., Usui M.,
Ashida Y. and Nishida E. Antagonism between the Master Regulators of
Differentiation Ensures the Discreteness and Robustness of Cell Fates. Mol. Cell 54(3):526-35.
(2014)
Koga M., Matsuda M., Kawamura T., Sogo T., Shigeno A., Nishida E. and Ebisuya M. Foxd1 is a mediator and indicator of the cell reprogramming process. Nat. Commun. 5:3197(2014)
2013
Negishi H., Matsuki K., Endo N.,
Sarashina H., Miki S., Matsuda A., Fukazawa K., Taguchi-Atarashi N., Ikushima
H., Yanai H., Nishio J., Honda K., Fujioka Y., Ohba Y., Noda T., Taniguchi S.,
Nishida E., Zhang Y., Chi H., Flavell RA. and Taniguchi T. Beneficial innate
signaling interference for antibacterial responses by a Toll-like
receptor-mediated enhancement of the MKP-IRF3 axis. Proc.
Natl. Acad. Sci. U S A. 110(49):19884-9 (2013)
Ohta S., Nishida E., Yamanaka S.
and Yamamoto T. Global Splicing Pattern Reversion during Somatic Cell
Reprogramming. Cell Rep. 5(2):357-66. (2013)
Takashima S., Hirose M., Ogonuki
N., Ebisuya M., Inoue K., Kanatsu-Shinohara M., Tanaka T., Nishida E., Ogura A.
and Shinohara T. Regulation of pluripotency in male germline stem cells by
Dmrt1.Genes Dev.
27(18):1949-58.
(2013)
Tsuchiya
Y., Taniguchi H., Ito Y., Morita T., Karim MR., Ohtake N., Fukagai K., Ito T.,
Okamuro S., Iemura S., Natsume T., Nishida E. and Kobayashi A. The casein
kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by
regulating proteasome gene expression. Mol. Cell Biol.
33(17):3461-72. (2013)
Uno M., Honjoh S., Matsuda M.,
Hoshikawa H., Kishimoto S., Yamamoto T., Ebisuya M., Yamamoto T., Matsumoto K.
and Nishida E. A Fasting-Responsive Signaling Pathway that Extends Life Span in
C. elegans. Cell Rep. 3(1):79-91. (2013)
Tsuchiya Y., Minami I., Kadotani
H., Todo T. and Nishida E. Circadian clock-controlled diurnal oscillation of
Ras/ERK signaling in mouse liver. Proc Jpn Acad Ser B Phys Biol Sci. 89(1):59-65.
(2013)
2012
Tanimura N., Saito M., Ebisuya M.,
Nishida E. and Ishikawa F. Stemness-related Factor Sall4 Interacts with
Transcription Factors Oct-3/4 and Sox2 and Occupies Oct-Sox Elements in Mouse
Embryonic Stem Cells. J Biol. Chem.
288(7):5027-38.(2012)
Takahashi C., Suzuki T., Nishida E.
and Kusakabe M. Identification and characterization of Xenopus kctd15, an ectodermal
gene repressed by the FGF pathway. Int J Dev Biol.
56(5):393-402. (2012)
Suzuki T., Kusakabe M., Nakayama K.
and Nishida E. The protein kinase MLTK regulates chondrogenesis by inducing the
transcription factor Sox6. Development 139(16):2988-98.
(2012)
Chujo M., Tarumoto Y., Miyatake K.,
Nishida E. and Ishikawa F. HIRA, a conserved histone chaperone, plays an
essential role in low-dose stress response via transcriptional stimulation in
fission yeast. J Biol. Chem.
287(28):23440-50.(2012)
Matsuda M., Koga M., Nishida E. and
Ebisuya M. Synthetic signal propagation through direct cell-cell interaction. Sci Signal.
5(220):ra31.(2012)
Matsumura S., Hamasaki M., Yamamoto
T., Ebisuya M., Sato M., Nishida E. and Toyoshima F. ABL1 regulates spindle
orientation in adherent cells and mammalian skin. Nat. Commun.
3:626 (2012)
Imajo M., Miyatake K., Iimura A.,
Miyamoto A. and Nishida E. A molecular mechanism that links Hippo signalling to
the inhibition of Wnt/β-catenin signalling. EMBO J. 31(5):1109-22. (2012)
2011
Miyata Y. and Nishida E. DYRK1A
binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its
nuclear translocation. Biochim Biophys Acta.
1813(10):1728-39 (2011)
Honjoh S. and Nishida E. Two sides
of lifespan regulating genes: pro-longevity or anti-longevity? J. Biochem. 149(4):381-8. (2011)
Sunadome K., Yamamoto T., Ebisuya
M., Kondoh K., Sehara-Fujisawa A. and Nishida
Endo T., Kusakabe M.,
Sunadome K., Yamamoto T. and Nishida E. The Kinase SGK1 in the Endoderm and
Mesoderm Promotes Ectodermal Survival by Down-Regulating Components of the
Death-Inducing Signaling Complex. Sci. Signal. 4(156): ra2. (2011 ) 【Summary】【Abstract】【Reprint】【Full
text】
Araki T., Kusakabe M. and Nishida
E. A transmembrane protein EIG121L is required for
epidermal differentiation during early embryonic development. J.
Biol. Chem. 286(8): 6760-6768 (2011 )
2010
Imajo M. and Nishida E. Human Tribbles homolog 1 functions as a
negative regulator of retinoic acid receptor. Genes
Cells 15(10):1089-1097
(2010)
Mitsushima M., Aoki K., Ebisuya M., Matsumura
S., Yamamoto T., Matsuda M., Toyoshima F and Nishida E. Revolving movement of a
dynamic cluster of actin filaments during mitosis. J.
Cell Biol. 191(3):453-462
(2010)
Akashi M., Soma H., Yamamoto T., Tsugitomi A.,
Yamashita S., Yamamoto T., Nishida E., Yasuda A., Liao JK and Node K.
Noninvasive method for assessing the human circadian clock using hair follicle
cells. Proc. Natl. Acad. Sci. U S A. 107(35):15643-15648
(2010)
Okuyama T., Inoue H., Ookuma S.,
Satoh T.,
Yamazaki T., Fujiwara N., Yukinaga
H., Ebisuya M., Shiki T., Kurihara T., Kioka N., Kambe T., Nagao M., Nishida
E., and Masuda S. The closely related RNA helicases, UAP56 and URH49,
preferentially form distinct mRNA export machineries and coordinately regulate
mitotic progression. Mol .
Biol. Cell. 16 2953-2965.
(2010)
Inoue H. and Nishida E. The DM
domain transcription factor MAB-3 regulates male hypersensitivity to oxidative
stress in Caenorhabditis elegans. Mol. Cell Biol. 14, 3453-3459 (2010)
Satoh T., Torii S., Nakayama K.,
and Nishida E. CrkL is a novel target of Sprouty2 in fibroblast growth factor
signaling. Genes
Cells 15(3) 161-168 (2010)
2009
Kosako H., Yamaguchi N., Aranami
C., Ushiyama M., Kose S., Imamoto N., Taniguchi H., Nishida E., and Hattori S.
Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to
nucleoporin-mediated nuclear transport. Nat.
Struct. Mol. Biol. 10
1026-1035 (2009)
Tsuchiya
Y.,
Hashimoto Y., Ookuma S., and
Nishida E. Lifespan extension by
suppression of autophagy genes in Caenorhabditis elegans. Genes
Cells 14, 717-726
(2009)
Mitsushima
M., Toyoshima F., and Nishida E. Dual role of Cdc42 in spindle orientation control of
adherent cells. Mol. Cell Biol. 29, 2816-2827 (2009)
Hanafusa H., Matsumoto K., and Nishida E. Regulation of ERK activity
duration by Sprouty contributes to dorsoventral patterning. Nature Cell Biol. 11, 106-109
(2009)
Honjoh S., Yamamoto T., Uno
M., and Nishida E. Signaling through RHEB-1 mediates intermittent
fasting-induced longevity in C. elegans.
Nature 457, 726-730
(2009)
2008
Mayer S. I., Willars G. B.,
Nishida E., and Thiel G. Elk-1, CREB, and MKP-1 regulateEgr-1 expression in
gonadotropin-releasing hormone stimulated gonadotrophs. J. Cell Biochem. 105,
1267-1278 (2008)
Mayer S. I., Dexheimer V.,
Nishida E., Kitajima S., and Thiel G. Expression of the transcriptional
repressor ATF3 in gonadotrophs is regulated by Egr-1, CREB, and ATF2 after
gonadotropin-releasing hormone receptor stimulation. Endocrinology 149, 6311-6325 (2008)
Hayashi H., Tsuchiya Y.,
Nakayama K., Satoh T., and Nishida E. Down-regulation of the PI3-kinase/Akt
pathway by ERK MAP kinase in growth factor signaling. Genes Cells 13, 941-947 (2008)
Ebisuya M.,
Yamamoto T., Nakajima M., and Nishida E. Ripples from neighbouring
transcription. Nature Cell Biol. 10, 1106-1113 (2008)
Miyata Y.,
and Nishida E. Evaluating CK2 activity with the antibody specific for the
CK2-phosphorylated form of a kinase-targeting cochaperone Cdc37. Mol.
Cell Biochem. 316, 127- 134 (2008)
Nakayama
K., Satoh T., Igari A., Kageyama R., and Nishida E. FGF induces oscillations of
Hes1 expression and Ras/ERK activation. Curr. Biol. 18, 332-334 (2008)
Nakajima
H., Yonemura S., Murata M., Nakamura N., Piwnica-Worms H., and Nishida E. Myt1
protein kinase is essential for Golgi and ER assembly during mitotic exit. J.
Cell Biol. 181, 89-103 (2008)
2007
Toyoshima
F., Matsumura S., Morimoto H., Mitsushima M., and Nishida E. PtdIns(3,4,5)P3
Regulates Spindle Orientation in Adherent Cells. Dev. Cell 13,
796-811 (2007).
Morimoto
H., Kondoh K., Nishimoto S., Terasawa K., and Nishida E. Activation of a
C-terminal transcriptional activation domain of ERK5 by autophsophorylation. J. Biol. Chem. 282, 35449-35456 (2007).
Miyata
Y., and Nishida E. Analysis of the CK2-dependent phosphorylation of serine 13
in Cdc37 using a phospho-specific antibody and phospho-affinity gel
electrophoresis. FEBS J. 274, 5690-5703 (2007).
Toyoshima
F., and Nishida E. Spindle orientation in animal cell mitosis: roles of
integrin in the control of spindle axis. J.
Cell Physiol. 213,
407-411 (2007).
Nishimoto
S., and Nishida E. Fibroblast growth factor 13 is essential for neural
differentiation in Xenopus early embryonic development. J. Biol. Chem. 282,
24255-24261 (2007).
Kondoh
K., and Nishida E. Regulation of MAP kinases by MAP kinase phosphatases. Biochim. Biophys. Acta. 1773, 1227-1237 (2007).
Maekawa
M., Yamamoto T., Kohno M., Takeichi M., and Nishida E. Requirement for ERK MAP
kinase in mouse preimplantation development. Development 134,
2751-2759 (2007).
Yamanaka
H., and Nishida E. Wnt11 stimulation induces polarized accumulation of
Dishevelled at apical adherens junctions through Frizzled7. Genes Cells 12, 961-967 (2007).
Araki
T., Kusakabe M., and Nishida E. Expression of estrogen induced gene 121-like
(EIG121L) during early Xenopus development. Gene Expr. Patterns 7, 666-671 (2007).
Matsumura
S., Toyoshima F., and Nishida E. Plk1 facilitates chromosome alignment
during prometaphase through BubR1. J.
Biol. Chem. 282,
15217-15227 (2007).
Toyoshima
F., and Nishida E. Integrin-mediated adhesion orients the spindle parallel to
the substratum in an EB1- and myosin X-dependent manner. EMBO J. 26,
1487-1498 (2007).
Machida
M., Kosako H., Shirakabe K., Kobayashi M., Ushiyama M., Inagawa J., Hirano
J., Nakano T., Bando Y., Nishida E., and Hattori S. Purification of
phosphoproteins by immobilized metal affinity chromatography and its
application to phosphoproteome analysis. FEBS
J. 274, 1576-1587
(2007).
Kondoh
K., Sunadome K., and Nishida E. Notch signaling suppresses p38 MAPK
activity via induction of MKP-1 in myogenesis. J. Biol. Chem. 282, 3058-3065 (2007).
2006
Nisimoto
S., and Nishida E. MAPK signalling: ERK5 versus ERK1/2. EMBO Rep. 7,
782-786 (2006).
Hyodo-Miura
J., Yamamoto TS., Hyodo AC., Iemura S., Kusakabe M., Nishida E., Natsume
T., and Ueno N. XGAP, an ArfGAP, is required for polarized
localization of PAR proteins and cell polarity in Xenopus gastrulation. Dev. Cell 11, 69-79 (2006).
Torii
S., Yamamoto T., Tsuchiya Y., and Nishida E. ERK MAP kinase in G cell cycle
progression and cancer. Cancer Sci.
97, 697-702 (2006).
Yamamoto
T., Ebisuya M., Ashida F., Okamoto K., Yonehara S., and Nishida E. Continuous
ERK Activation Downregulates Antiproliferative Genes throughout G1 Phase to
Allow Cell-Cycle Progression. Curr.
Biol. 16, 1171-1182
(2006).
Imajo
M., Tsuchiya Y., and Nishida E. Regulatory mechanisms and functions of MAP
kinase signaling pathways. IUBMB Life
58, 312-317 (2006).
Kondoh
K., Terasawa K., Morimoto H., and Nishida E Regulation of nuclear translocation
of extracellular signal-regulated kinase 5 by active nuclear import and export
mechanisms. Mol. Cell. Biol.26, 1679-1690 (2006).
Fujioka
A., Terai K., Itoh RE., Aoki K., Nakamura T., Kuroda S., Nishida E., Matsuda M.
Dynamics of the Ras/ERK MAPK cascade as monitored by fluorescent probes. J. Biol. Chem.281, 8917-8926 (2006).
Hayashi
H., Matsuzaki O., Muramatsu S., Tsuchiya Y., Harada T., Suzuki Y., Sugano S.,
Matsuda A., and Nishida E. Centaurin-alpha1 is a phosphatidylinositol
3-kinase-dependent activator of ERK1/2 mitogen-activated protein kinases. J. Biol. Chem. 281, 1332-1337 (2006).
2005
iyata
Y., and Nishida E. CK2 binds, phosphorylates, and regulates its pivotal
substrate Cdc37, an Hsp90-cochaperone. Mol.
Cell. Biochem. 274,
171-179 (2005).
Nishimoto
S., Kusakabe M., and Nishida E. Requirement of the MEK5-ERK5 pathway for neural
differentiation in Xenopus embryonic development. EMBO Rep. 6,
1064-1069 (2005).
Inoue
H., Hisamoto N., An JH., Oliveira RP., Nishida E., Blackwell TK., and Matsumoto
K. The C. elegans p38 MAPK pathway regulates nuclear localization of the
transcription factor SKN-1 in oxidative stress response. Genes Dev. 19,
2278-2283 (2005)
Ebisuya,
M., Kondoh, K. and Nishida, E. The duration, magnitude and compartmentalization
of ERK MAP kinase activity: mechanisms for providing signaling specificity. J. Cell Sci. 118, 2997-3002 (2005).
Kondoh,
K., Torii, S. and Nishida, E. Control of MAP kinase signaling to the nucleus. Chromosoma 114, 86-91 (2005).
Yasunaga,
T., Kusakabe, M., Yamanaka, H., Hanafusa, H., Masuyama, N. and Nishida, E.
Xenopus ILK (integrin-linked kinase) is required for morphogenetic movements
during gastrulation. Genes Cells
10, 369-379 (2005).
Maekawa,
M., Yamamoto, T., Tanoue, T., Yuasa, Y., Chisaka, O. and Nishida, E. Requirement
of the MAP kinase signaling pathways for mouse preimplantation development. Development 132, 1773-1783 (2005).
Tsuchiya,
Y., Minami,
2004
Miyat
Y., and Nishida E. Supervision of multiple signaling protein kinases by the
CK2-Cdc37 couple, a possible novel cancer therapeutic target. Ann. N. Y. Acad. Sci. 1030, 150-157 (2004).
Torii,
S., Nakayama, K., Yamamoto, T. and Nishida, E. Regulatory mechanisms and
function of ERK MAP kinases. J.
Biochem. (
Kusakabe,
M. and Nishida, E. The polarity-inducing kinase Par-1 controls Xenopus
gastrulation in cooperation with 14-3-3 and aPKC. EMBO J. 23,
4190-4201 (2004).
Torii,
S., Kusakabe, M., Yamamoto, T., Maekawa, M. and Nishida,
Matsuda,
S., Miwa, Y., Hirata, Y., Minowa, A., Tanaka, J., Nishida, E. and Koyasu, S.
Negative feedback loop in T-cell activation through MAPK-catalyzed threonine
phosphorylation of LAT. EMBO J.
23, 2577-2585 (2004).
Mizuno,
T., Hisamoto, N., Terada, T., Kondo, T., Adachi, M., Nishida, E., Kim, D. H.,
Ausubel, F. M. and Matsumoto, K. The Caenorhabditis elegans MAPK phosphatase
VHP-1 mediates a novel JNK-like signaling pathway in stress response. EMBO J. 23, 2226-2234 (2004).
Matsubayashi,
Y., Ebisuya, M., Honjoh, S. and Nishida,
Miyata,
Y. and Nishida, E. CK2 controls multiple protein kinases by phosphorylating a
kinase-targeting molecular chaperone, Cdc37. Mol. Cell Biol. 24, 4065-4074
(2004).
Maekawa,
M., Yamamoto, T. and Nishida, E. Regulation of subcellular localization of the
antiproliferative protein Tob by its nuclear export signal and bipartite
nuclear localization signal sequences. Exp.
Cell Res. 295, 59-65
(2004).
Hanafusa,
H., Torii, S., Yasunaga, T., Matsumoto, K. and Nishida, E. Shp2, an
SH2-containing protein-tyrosine phosphatase, positively regulates receptor
tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor
Sprouty. J. Biol. Chem. 279, 22992-22995 (2004).
Ogawa,
S., Matsubayashi, Y. and Nishida, E. An evolutionarily conserved gene required
for proper microtubule architecture in Caenorhabditis elegans. Genes Cells 9, 83-93 (2004).
Adachi,
M. and Nishida, E. Subcellular localization of MAPKs. Methods Mol. Biol. 250, 145-154 (2004).
2003
Tsuchiya,
Y. and Nishida, E. Mammalian cultured cells as a model system of peripheral
circadian clocks. J. Biochem. (
Nishimura
M., Sugino T., Nozaki K., Takagi Y., Hattori I., Hayashi J., Hashimoto N., Moriguchi
T., and Nishida E Activation of p38 kinase in the gerbil hippocampus showing
ischemic tolerance. J. Cereb. Blood
Flow Metab. 23,1052-1059
(2003).
Tsuchiya,
Y.,
Matsuda
A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T.,
Shimotohno K., Harada T., Nishida E., Hayashi H., and Sugano S. Large-scale
identification and characterization of human genes that activate NF-kappaB and
MAPK signaling pathways. Oncogene
22, 3307-3318 (2003).
Nakajima,
H., Toyoshima-Morimoto, F., Taniguchi, E. and Nishida, E. Identification of a
consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a
Plk1 substrate. J. Biol. Chem. 278, 25277-25280 (2003).
Harada
T., Matsuzaki O., Hayashi H., Sugano S., Matsuda A., and Nishida E AKRL1 and
AKRL2 activate the JNK pathway. Genes
Cells 8, 493-500
(2003).
Tanoue
T., and Nishida E. Molecular recognitions in the MAP kinase cascades. Cell. Signal. 15, 455-462 (2003).
Terasawa,
K., Okazaki, K. and Nishida, E. Regulation of c-Fos and Fra-1 by the MEK5-ERK5
pathway. Genes Cells 8, 263-273 (2003).
Ookuma,
S., Fukuda, M. and Nishida, E. Identification of a DAF-16 transcriptional
target gene, scl-1, that regulates longevity and stress resistance in
Caenorhabditis elegans. Curr. Biol.
13, 427-431 (2003).
Kawachi,
K., Masuyama, N. and Nishida, E. Essential role of the transcription factor
Ets-2 in Xenopus early development. J.
Biol. Chem. 278,
5473-5477 (2003).
2002
Hanafusa,
H., Torii, S., Yasunaga, T. and Nishida,
Taniguchi,
E., Toyoshima-Morimoto, F. and Nishida, E. Nuclear translocation of plk1
mediated by its bipartite nuclear localization signal. J. Biol. Chem. 277, 48884-48888 (2002).
Tanoue
T., and Nishida E. Docking interactions in the mitogen-activated protein kinase
cascades. Pharmacol. Ther. 93, 193-202 (2002).
Maekawa,
M., Nishida, E. and Tanoue, T. Identification of the Anti-proliferative protein
Tob as a MAPK substrate. J. Biol.
Chem. 277, 37783-37787
(2002).
Tanoue
T., Yamamoto T., and Nishida E Modular structure of a docking surface on MAPK
phosphatases. J. Biol. Chem. 277, 22942-22949 (2002).
Bamba,
C., Bobinnec, Y., Fukuda, M. and Nishida, E. The GTPase Ran regulates
chromosome positioning and nuclear envelope assembly in vivo. Curr. Biol. 12, 503-507 (2002).
Toyoshima-Morimoto,
F., Taniguchi, E. and Nishida, E. Plk1 promotes nuclear translocation of human
Cdc25C during prophase. EMBO Rep.
3, 341-348 (2002).
Yamanaka,
H., Moriguchi, T., Masuyama, N., Kusakabe, M., Hanafusa, H., Takada, R.,
Takada, S. and Nishida,
2001
Kusakabe,
M., Masuyama, N., Hanafusa, H. and Nishida, E. Xenopus FRS2 is involved in
early embryogenesis in cooperation with the Src family kinase Laloo. EMBO Rep. 2, 727-735 (2001).
Matsubayashi,
Y., Fukuda, M. and Nishida, E. Evidence for existence of a nuclear pore
complex-mediated, cytosol-independent pathway of nuclear translocation of ERK
MAP kinase in permeabilized cells. J.
Biol. Chem. 276,
41755-41760 (2001).
Harada,
T., Morooka, T., Ogawa, S. and Nishida, E. ERK induces p35, a neuron-specific
activator of Cdk5, through induction of Egr1. Nat. Cell Biol. 3,
453-459 (2001).
Asano,
S., Mishima, M. and Nishida, E. Coronin forms a stable dimer through its
C-terminal coiled coil region: an implicated role in its localization to cell
periphery. Genes Cells 6, 225-235 (2001).
Gotoh,
Tanoue,
T., Maeda, R., Adachi, M. and Nishida, E. Identification of a docking groove on
ERK and p38 MAP kinases that regulates the specificity of docking interactions.
EMBO J. 20, 466-479 (2001).
Toyoshima-Morimoto,
F., Taniguchi, E., Shinya, N., Iwamatsu, A. and Nishida, E. Polo-like kinase 1
phosphorylates cyclin B1 and targets it to the nucleus during prophase. Nature 410, 215-220 (2001).
Tanoue,
T., Yamamoto, T., Maeda, R. and Nishida, E. A Novel MAPK phosphatase MKP-7 acts
preferentially on JNK/SAPK and p38 alpha and beta MAPKs. J. Biol. Chem. 276, 26629-26639 (2001).
Miyata,
Y., Ikawa, Y., Shibuya, M. and Nishida, E. Specific association of a set of
molecular chaperones including HSP90 and Cdc37 with MOK, a member of the
mitogen-activated protein kinase superfamily. J. Biol. Chem. 276, 21841-21848 (2001).
Mizuno,
H. and Nishida, E. The ERK MAP kinase pathway mediates induction of SGK (serum-
and glucocorticoid-inducible kinase) by growth factors. Genes Cells 6,
261-268 (2001).
2000
Ellinger-Ziegelbauer,
H., Karasuyama, H., Yamada, E., Tsujikawa, K., Todokoro, K. and Nishida, E.
Ste20-like kinase (SLK), a regulatory kinase for polo-like kinase (Plk) during
the G2/M transition in somatic cells. Genes
Cells 5, 491-498
(2000).
Hanafusa,
H., Masuyama, N., Kusakabe, M., Shibuya, H. and Nishida, E. The TGF-beta family
member derriere is involved in regulation of the establishment of left-right
asymmetry. EMBO Rep. 1, 32-39 (2000).
Bobinnec,
Y., Fukuda, M. and Nishida, E. Identification and characterization of
Caenorhabditis elegans gamma-tubulin in dividing cells and differentiated
tissues. J. Cell Sci. 113.
Pt. 21, 3747-3759
(2000).
Adachi,
M., Fukuda, M. and Nishida, E. Nuclear export of MAP kinase (ERK) involves a
MAP kinase kinase (MEK)-dependent active transport mechanism. J. Cell Biol. 148, 849-856 (2000).
Sugino,
T., Nozaki, K., Takagi, Y., Hattori,
Watanabe,
M., Masuyama, N., Fukuda, M. and Nishida, E. Regulation of intracellular
dynamics of Smad4 by its leucine-rich nuclear export signal. EMBO Rep. 1, 176-182 (2000).
Tanoue,
T., Adachi, M., Moriguchi, T. and Nishida, E. A conserved docking motif in MAP
kinases common to substrates, activators and regulators. Nat. Cell Biol. 2, 110-116 (2000).
Kurokawa,
M., Mitani, K., Yamagata, T., Takahashi, T., Izutsu, K., Ogawa, S., Moriguchi,
T., Nishida, E., Yazaki, Y. and Hirai, H. The evi-1 oncoprotein inhibits c-Jun
N-terminal kinase and prevents stress-induced cell death. EMBO J. 19,
2958-2968 (2000).
Matsuda,
S., Shibasaki, F., Takehana, K., Mori, H., Nishida, E. and Koyasu, S. Two
distinct action mechanisms of immunophilin-ligand complexes for the blockade of
T-cell activation. EMBO Rep.
1, 428-434 (2000).
1999
Kawasaki,
H., Fujii, H., Gotoh, Y., Morooka, T., Shimohama, S., Nishida, E. and Hirano,
T. Requirement for mitogen-activated protein kinase in cerebellar long term
depression. J. Biol. Chem. 274, 13498-13502 (1999).
Masuyama,
N., Hanafusa, H., Kusakabe, M., Shibuya, H. and Nishida, E. Identification of
two Smad4 proteins in Xenopus. Their common and distinct properties. J.
Biol. Chem. 274, 12163-12170 (1999).
Matsumoto,
Y., Hayashi, K. and Nishida, E. Cyclin-dependent kinase 2 (Cdk2) is required
for centrosome duplication in mammalian cells. Curr. Biol. 9, 429-432
(1999).
Adachi,
M., Fukuda, M. and Nishida, E. Two co-existing mechanisms for nuclear import of
MAP kinase: passive diffusion of a monomer and active transport of a dimer. EMBO
J. 18, 5347-5358 (1999).
Gotoh,
Hanafusa,
H., Ninomiya-Tsuji, J., Masuyama, N., Nishita, M.,
Tanoue,
T., Moriguchi, T. and Nishida, E. Molecular cloning and characterization of a
novel dual specificity phosphatase, MKP-5. J. Biol. Chem. 274,
19949-19956 (1999).
Yamaguchi,
K., Nagai, S., Ninomiya-Tsuji, J., Nishita, M., Tamai, K., Irie, K., Ueno, N.,
Nishida, E., Shibuya, H. and Matsumoto, K. XIAP, a cellular member of the
inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the
BMP signaling pathway. EMBO J. 18, 179-187 (1999).
Watanabe,
M., Fukuda, M., Yoshida, M., Yanagida, M. and Nishida, E. Involvement of CRM1,
a nuclear export receptor, in mRNA export in mammalian cells and fission yeast.
Genes Cells 4, 291-297 (1999).
Moriguchi,
T., Kawachi, K., Kamakura, S., Masuyama, N., Yamanaka, H., Matsumoto, K.,
Kikuchi, A. and Nishida, E. Distinct domains of mouse dishevelled are
responsible for the c-Jun N-terminal kinase/stress-activated protein kinase
activation and the axis formation in vertebrates. J. Biol. Chem. 274,
30957-30962 (1999).
Mishima,
M. and Nishida, E. Coronin localizes to leading edges and is involved in cell
spreading and lamellipodium extension in vertebrate cells. J. Cell Sci. 112,
2833-2842 (1999).
Miyata,
Y., Adachi, S., Mizuno, H. and Nishida, E. A strategy to make constitutively
active MAP kinase by fusing with constitutively active MAP kinase kinase. Biochim.
Biophys. Acta. 1451, 334-342 (1999).
Miyata,
Y. and Nishida, E. Distantly related cousins of MAP kinase: biochemical
properties and possible physiological functions. Biochem. Biophys. Res.
Commun. 266, 291-295 (1999).
1998
hibuya,
H., Iwata, H., Masuyama, N., Gotoh, Y., Yamaguchi, K., Irie, K., Matsumoto, K.,
Nishida, E. and Ueno, N. Role of TAK1 and TAB1 in BMP signaling in early
Xenopus development. EMBO J. 17, 1019-1028 (1998).
Sugawara,
T., Moriguchi, T., Nishida, E. and Takahama, Y. Differential roles of ERK and p38
MAP kinase pathways in positive and negative selection of T lymphocytes. Immunity
9, 565-574 (1998).
Matsuda,
S., Moriguchi, T., Koyasu, S. and Nishida, E. T lymphocyte activation signals
for interleukin-2 production involve activation of MKK6-p38 and MKK7-SAPK/JNK
signaling pathways sensitive to cyclosporin A. J. Biol. Chem. 273,
12378-12382 (1998).
Morooka,
T. and Nishida, E. Requirement of p38 mitogen-activated protein kinase for
neuronal differentiation in PC12 cells. J. Biol. Chem. 273, 24285-24288
(1998).
Takenaka,
K., Moriguchi, T. and Nishida, E. Activation of the protein kinase p38 in the
spindle assembly checkpoint and mitotic arrest. Science 280, 599-602
(1998).
Yang,
N., Higuchi, O., Ohashi, K., Nagata, K., Wada, A., Kangawa, K., Nishida, E. and
Mizuno, K. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated
actin reorganization. Nature 393, 809-812 (1998).
Yoneyama,
M., Suhara, W., Fukuhara, Y., Fukuda, M., Nishida, E. and Fujita, T. Direct
triggering of the type I interferon system by virus infection: activation of a
transcription factor complex containing IRF-3 and CBP/p300. EMBO J. 17,
1087-1095 (1998).
Toyoshima,
F., Moriguchi, T., Wada, A., Fukuda, M. and Nishida, E. Nuclear export of
cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint. EMBO
J. 17, 2728-2735 (1998).
Wada,
A., Fukuda, M., Mishima, M. and Nishida, E. Nuclear export of actin: a novel
mechanism regulating the subcellular localization of a major cytoskeletal
protein. EMBO J. 17, 1635-1641 (1998).
1997
Shirakabe,
K., Yamaguchi, K., Shibuya, H., Irie, K., Matsuda, S., Moriguchi, T., Gotoh,
Y., Matsumoto, K. and Nishida, E. TAK1 mediates the ceramide signaling to
stress-activated protein kinase/c-Jun N-terminal kinase. J. Biol. Chem. 272,
8141-8144 (1997).
Takenaka,
K., Gotoh, Y. and Nishida, E. MAP kinase is required for the spindle assembly
checkpoint but is dispensable for the normal M phase entry and exit in Xenopus
egg cell cycle extracts. J. Cell Biol. 136, 1091-1097
(1997).
Toyoshima,
F., Moriguchi, T. and Nishida, E. Fas induces cytoplasmic apoptotic responses
and activation of the MKK7-JNK/SAPK and MKK6-p38 pathways independent of
CPP32-like proteases. J. Cell Biol. 139, 1005-1015 (1997).
Fukuda,
M., Gotoh, Y. and Nishida, E. Interaction of MAP kinase with MAP kinase kinase:
its possible role in the control of nucleocytoplasmic transport of MAP kinase. EMBO
J. 16, 1901-1908 (1997).
Huang,
S., Jiang, Y., Li, Z., Nishida, E., Mathias, P., Lin, S., Ulevitch, R. J.,
Nemerow, G. R. and Han, J. Apoptosis signaling pathway in T cells is composed
of ICE/Ced-3 family proteases and MAP kinase kinase 6b. Immunity 6,
739-749 (1997).
Fukuda,
M., Gotoh, I., Adachi, M., Gotoh, Y. and Nishida, E. A novel regulatory mechanism
in the mitogen-activated protein (MAP) kinase cascade. Role of nuclear export
signal of MAP kinase kinase. J. Biol. Chem. 272, 32642-32648
(1997).
Fukuda,
M., Asano, S., Nakamura, T., Adachi, M., Yoshida, M., Yanagida, M. and Nishida,
E. CRM1 is responsible for intracellular transport mediated by the nuclear
export signal. Nature 390, 308-311 (1997).
Kuramochi,
S., Moriguchi, T., Kuida, K., Endo, J., Semba, K., Nishida, E. and Karasuyama,
H. LOK is a novel mouse STE20-like protein kinase that is expressed
predominantly in lymphocytes. J. Biol. Chem. 272, 22679-22684
(1997).
Moriguchi,
T., Toyoshima, F., Masuyama, N., Hanafusa, H., Gotoh, Y. and Nishida, E. A
novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses. EMBO
J. 16, 7045-7053 (1997).
Ichijo,
H., Nishida, E., Irie, K., ten Dijke, P., Saitoh, M., Moriguchi, T., Takagi,
M., Matsumoto, K., Miyazono, K. and Gotoh, Y. Induction of apoptosis by ASK1, a
mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science
275, 90-94 (1997).
Kawasaki,
H., Morooka, T., Shimohama, S., Kimura, J., Hirano, T., Gotoh, Y. and Nishida,
E. Activation and involvement of p38 mitogen-activated protein kinase in
glutamate-induced apoptosis in rat cerebellar granule cells. J. Biol. Chem.
272, 18518-18521 (1997).
1996
Fukuda,
M., Gotoh, I., Gotoh, Y. and Nishida, E. Cytoplasmic localization of
mitogen-activated protein kinase kinase directed by its NH2-terminal,
leucine-rich short amino acid sequence, which acts as a nuclear export signal. J.
Biol. Chem. 271, 20024-20028 (1996).
Gotoh,
Y. and Nishida, E. Signals for mesoderm induction. Roles of fibroblast growth
factor (FGF)/mitogen-activated protein kinase (MAPK) pathway. Biochim.
Biophys. Acta. 1288, F1-F7 (1996).
Moriguchi,
T., Kuroyanagi, N., Yamaguchi, K., Gotoh, Y., Irie, K., Kano, T., Shirakabe,
K., Muro, Y., Shibuya, H., Matsumoto, K., Nishida, E. and Hagiwara, M. A novel
kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. J.
Biol. Chem. 271, 13675-13679 (1996).
Kawasaki,
H., Moriguchi, T., Matsuda, S., Li, H. Z., Nakamura, S., Shimohama, S., Kimura,
J., Gotoh, Y. and Nishida, E. Ras-dependent and Ras-independent activation
pathways for the stress-activated-protein-kinase cascade. Eur. J. Biochem.
241, 315-321 (1996).
Shibuya,
H., Yamaguchi, K., Shirakabe, K., Tonegawa, A., Gotoh, Y., Ueno, N., Irie, K.,
Nishida, E. and Matsumoto, K. TAB1: an activator of the TAK1 MAPKKK in TGF-beta
signal transduction. Science 272, 1179-1182 (1996).
Moriguchi,
T., Toyoshima, F., Gotoh, Y., Iwamatsu, A., Irie, K., Mori, E., Kuroyanagi, N.,
Hagiwara, M., Matsumoto, K. and Nishida, E. Purification and identification of
a major activator for p38 from osmotically shocked cells. Activation of
mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis
factor-alpha, and H2O2. J. Biol. Chem. 271, 26981-26988
(1996).
Kosako,
H., Akamatsu, Y., Tsurushita, N., Lee, K. K., Gotoh, Y. and Nishida, E.
Isolation and characterization of neutralizing single-chain antibodies against
Xenopus mitogen-activated protein kinase kinase from phage display libraries. Biochemistry
35, 13212-13221 (1996).
1995
Gotoh,
Y. and Nishida, E. Activation mechanism and function of the MAP kinase cascade.
Mol. Reprod. Dev. 42, 486-492 (1995).
Gotoh,
Y., Masuyama, N., Suzuki, A., Ueno, N. and Nishida, E. Involvement of the MAP
kinase cascade in Xenopus mesoderm induction. EMBO J. 14, 2491-2498
(1995).
Fukuda,
M., Gotoh, Y., Tachibana, T., Dell, K., Hattori, S., Yoneda, Y. and Nishida, E.
Induction of neurite outgrowth by MAP kinase in PC12 cells. Oncogene 11,
239-244 (1995).
Gotoh,
Y., Masuyama, N., Dell, K., Shirakabe, K. and Nishida, E. Initiation of Xenopus
oocyte maturation by activation of the mitogen-activated protein kinase
cascade. J. Biol. Chem. 270, 25898-25904 (1995).
Kato,
S., Endoh, H., Masuhiro, Y., Kitamoto, T., Uchiyama, S., Sasaki, H., Masushige,
S., Gotoh, Y., Nishida, E. and Kawashima, H. Activation of the estrogen
receptor through phosphorylation by mitogen-activated protein kinase. Science
270, 1491-1494 (1995).
Moriguchi,
T., Gotoh, Y. and Nishida, E. Activation of two isoforms of mitogen-activated
protein kinase kinase in response to epidermal growth factor and nerve growth
factor. Eur. J. Biochem. 234, 32-38 (1995).
Yamaguchi,
K., Shirakabe, K., Shibuya, H., Irie, K., Oishi, I., Ueno, N., Taniguchi, T.,
Nishida, E. and Matsumoto, K. Identification of a member of the MAPKKK family
as a potential mediator of TGF-beta signal transduction. Science 270,
2008-2011 (1995).
Matsuda,
S., Kawasaki, H., Moriguchi, T., Gotoh, Y. and Nishida, E. Activation of
protein kinase cascades by osmotic shock. J. Biol. Chem. 270, 12781-12786
(1995).
Moriguchi,
T., Kawasaki, H., Matsuda, S., Gotoh, Y. and Nishida, E. Evidence for multiple
activators for stress-activated protein kinase/c-Jun amino-terminal kinases.
Existence of novel activators. J. Biol. Chem. 270, 12969-12972
(1995).
1994
Irie,
K., Gotoh, Y., Yashar, B. M., Errede, B., Nishida, E. and Matsumoto, K. Stimulatory
effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase. Science
265, 1716-1719 (1994).
Kosako,
H., Gotoh, Y. and Nishida, E. Requirement for the MAP kinase kinase/MAP kinase
cascade in Xenopus oocyte maturation. EMBO J. 13, 2131-2138
(1994).
Fukuda,
M., Gotoh, Y., Kosako, H., Hattori, S. and Nishida, E. Analysis of the Ras
p21/mitogen-activated protein kinase signaling in vitro and in Xenopus oocytes.
J. Biol. Chem. 269, 33097-33101 (1994).
Gotoh,
Y., Matsuda, S., Takenaka, K., Hattori, S., Iwamatsu, A., Ishikawa, M., Kosako,
H. and Nishida, E. Characterization of recombinant Xenopus MAP kinase kinases
mutated at potential phosphorylation sites. Oncogene 9, 1891-1898
(1994).
Kosako,
H., Gotoh, Y. and Nishida, E. Regulation and function of the MAP kinase cascade
in Xenopus oocytes. J. Cell Sci. Suppl. 18, 115-119
(1994).
Shiina,
N., Gotoh, Y., Kubomura, N., Iwamatsu, A. and Nishida, E. Microtubule severing
by elongation factor 1 alpha. Science 266, 282-285 (1994).
Ueki,
K., Matsuda, S., Tobe, K., Gotoh, Y., Tamemoto, H., Yachi, M., Akanuma, Y.,
Yazaki, Y., Nishida, E. and Kadowaki, T. Feedback regulation of
mitogen-activated protein kinase kinase kinase activity of c-Raf-1 by insulin
and phorbol ester stimulation. J. Biol. Chem. 269, 15756-15761
(1994).
Kosako,
H., Gotoh, Y. and Nishida, E. Mitogen-activated protein kinase kinase is
required for the mos-induced metaphase arrest. J. Biol. Chem. 269,
28354-28358 (1994).
Mizoguchi,
T., Gotoh, Y., Nishida, E., Yamaguchi-Shinozaki, K., Hayashida, N., Iwasaki,
T., Kamada, H. and Shinozaki, K. Characterization of two cDNAs that encode MAP
kinase homologues in Arabidopsis thaliana and analysis of the possible role of
auxin in activating such kinase activities in cultured cells. Plant J. 5,
111-122 (1994).
1993
Kosako,
H., Nishida, E. and Gotoh, Y. cDNA cloning of MAP kinase kinase reveals kinase
cascade pathways in yeasts to vertebrates. EMBO J. 12, 787-794
(1993).
Iida,
K., Moriyama, K., Matsumoto, S., Kawasaki, H., Nishida, E. and Yahara, I.
Isolation of a yeast essential gene, COF1, that encodes a homologue of
mammalian cofilin, a low-M(r) actin-binding and depolymerizing protein. Gene
124, 115-120 (1993).
Gotoh,
Y., Nishida, E., Shimanuki, M., Toda, T., Imai, Y. and Yamamoto, M. Schizosaccharomyces
pombe Spk1 is a tyrosine-phosphorylated protein functionally related to Xenopus
mitogen-activated protein kinase. Mol. Cell. Biol. 13, 6427-6434
(1993).
Nishida,
E. and Gotoh, Y. The MAP kinase cascade is essential for diverse signal
transduction pathways. Trends Biochem. Sci. 18, 128-131
(1993).
Matsuda,
S., Gotoh, Y. and Nishida, E. Phosphorylation of Xenopus mitogen-activated
protein (MAP) kinase kinase by MAP kinase kinase kinase and MAP kinase. J.
Biol. Chem. 268, 3277-3281 (1993).
Lee,
K. S., Irie, K., Gotoh, Y., Watanabe, Y., Araki, H., Nishida, E., Matsumoto, K.
and Levin, D. E. A yeast mitogen-activated protein kinase homolog (Mpk1p)
mediates signalling by protein kinase C. Mol. Cell. Biol. 13, 3067-3075
(1993).
1992
Matsuda,
S., Kosako, H., Takenaka, K., Moriyama, K., Sakai, H., Akiyama, T., Gotoh, Y.
and Nishida, E. Xenopus MAP kinase activator: identification and function as a
key intermediate in the phosphorylation cascade. EMBO J. 11, 973-982
(1992).
Moriyama,
K., Yonezawa, N., Sakai, H., Yahara, I. and Nishida, E. Mutational analysis of
an actin-binding site of cofilin and characterization of chimeric proteins
between cofilin and destrin. J. Biol. Chem. 267, 7240-7244
(1992).
Hattori,
S., Fukuda, M., Yamashita, T., Nakamura, S., Gotoh, Y. and Nishida, E.
Activation of mitogen-activated protein kinase and its activator by ras in
intact cells and in a cell-free system. J. Biol. Chem. 267, 20346-20351
(1992).
Kosako,
H., Gotoh, Y., Matsuda, S., Ishikawa, M. and Nishida, E. Xenopus MAP kinase
activator is a serine/threonine/tyrosine kinase activated by threonine
phosphorylation. EMBO J. 11, 2903-2908 (1992).
Shiina,
N., Moriguchi, T., Ohta, K., Gotoh, Y. and Nishida, E. Regulation of a major
microtubule-associated protein by MPF and MAP kinase. EMBO J. 11,
3977-3984 (1992).
Shirakabe,
K., Gotoh, Y. and Nishida, E. A mitogen-activated protein (MAP) kinase
activating factor in mammalian mitogen-stimulated cells is homologous to
Xenopus M phase MAP kinase activator. J. Biol. Chem. 267, 16685-16690
(1992).
Nishida,
E. and Gotoh, Y. Mitogen-activated protein kinase and cytoskeleton in mitogenic
signal transduction. Int. Rev. Cytol. 138, 211-238 (1992).
Shiina,
N., Gotoh, Y. and Nishida, E. A novel homo-oligomeric protein responsible for
an MPF-dependent microtubule-severing activity. EMBO J. 11, 4723-4731
(1992).
1991
Gotoh,
Y., Moriyama, K., Matsuda, S., Okumura, E., Kishimoto, T., Kawasaki, H.,
Suzuki, K., Yahara, I., Sakai, H. and Nishida, E. Xenopus M phase MAP kinase: isolation
of its cDNA and activation by MPF. EMBO J. 10, 2661-2668
(1991).
Gotoh,
Y., Nishida, E., Matsuda, S., Shiina, N., Kosako, H., Shiokawa, K., Akiyama,
T., Ohta, K. and Sakai, H. In vitro effects on microtubule dynamics of purified
Xenopus M phase-activated MAP kinase. Nature 349, 251-254
(1991).
Yonezawa,
N., Nishida, E., Iida, K., Kumagai, H., Yahara, I. and Sakai, H. Inhibition of
actin polymerization by a synthetic dodecapeptide patterned on the sequence
around the actin-binding site of cofilin. J. Biol. Chem. 266, 10485-10489
(1991).
Yonezawa,
N., Homma, Y., Yahara, I., Sakai, H. and Nishida, E. A short sequence
responsible for both phosphoinositide binding and actin binding activities of
cofilin. J. Biol. Chem. 266, 17218-17221 (1991).
1990
Gotoh,
Y., Nishida, E., Yamashita, T., Hoshi, M., Kawakami, M. and Sakai, H.
Microtubule-associated-protein (MAP) kinase activated by nerve growth factor
and epidermal growth factor in PC12 cells. Identity with the mitogen-activated
MAP kinase of fibroblastic cells. Eur. J. Biochem. 193, 661-669
(1990).
Gotoh,
Y., Nishida, E. and Sakai, H. Okadaic acid activates microtubule-associated
protein kinase in quiescent fibroblastic cells. Eur. J. Biochem. 193,
671-674 (1990).
Hoshi,
M., Nishida, E., Inagaki, M., Gotoh, Y. and Sakai, H. Activation of a
serine/threonine kinase that phosphorylates microtubule-associated protein 1B
in vitro by growth factors and phorbol esters in quiescent rat fibroblastic
cells. Eur. J. Biochem. 193, 513-519 (1990).
Yonezawa,
N., Nishida, E., Iida, K., Yahara, I. and Sakai, H. Inhibition of the
interactions of cofilin, destrin, and deoxyribonuclease I with actin by
phosphoinositides. J. Biol. Chem. 265, 8382-8386 (1990).
Moriyama,
K., Nishida, E., Yonezawa, N., Sakai, H., Matsumoto, S., Iida, K. and Yahara,
I. Destrin, a mammalian actin-depolymerizing protein, is closely related to
cofilin. Cloning and expression of porcine brain destrin cDNA. J. Biol.
Chem. 265, 5768-5773 (1990).
1989
Koyasu,
S., Nishida, E., Miyata, Y., Sakai, H. and Yahara, I. HSP100, a 100-kDa heat
shock protein, is a Ca2+-calmodulin-regulated actin-binding protein. J.
Biol. Chem. 264, 15083-15087 (1989).
Hoshi,
M., Nishida, E. and Sakai, H. Characterization of a mitogen-activated, Ca2+-sensitive
microtubule-associated protein-2 kinase. Eur. J. Biochem. 184,
477-486 (1989).
Miyata,
Y., Nishida, E., Koyasu, S., Yahara, I. and Sakai, H. Protein kinase
C-dependent and -independent pathways in the growth factor-induced cytoskeletal
reorganization. J. Biol. Chem. 264, 15565-15568 (1989).
Yonezawa,
N., Nishida, E., Ohba, M., Seki, M., Kumagai, H. and Sakai, H. An
actin-interacting heptapeptide in the cofilin sequence. Eur. J. Biochem.
183, 235-238 (1989).
Ohta,
Y., Nishida, E., Sakai, H. and Miyamoto, E. Dephosphorylation of cofilin
accompanies heat shock-induced nuclear accumulation of cofilin. J. Biol.
Chem. 264, 16143-16148 (1989).
1988
Hoshi,
M., Akiyama, T., Shinohara, Y., Miyata, Y., Ogawara, H., Nishida, E. and Sakai,
H. Protein-kinase-C-catalyzed phosphorylation of the microtubule-binding domain
of microtubule-associated protein 2 inhibits its ability to induce tubulin
polymerization. Eur. J. Biochem. 174, 225-230 (1988).
Hoshi,
M., Nishida, E. and Sakai, H. Activation of a Ca2+-inhibitable protein kinase
that phosphorylates microtubule-associated protein 2 in vitro by growth
factors, phorbol esters, and serum in quiescent cultured human fibroblasts. J.
Biol. Chem. 263, 5396-5401 (1988).
Matsuzaki,
F., Matsumoto, S., Yahara, I., Yonezawa, N., Nishida, E. and Sakai, H. Cloning
and characterization of porcine brain cofilin cDNA. Cofilin contains the
nuclear transport signal sequence. J. Biol. Chem. 263, 11564-11568
(1988).
Nishida,
E., Tobe, K., Kadowaki, T., Kasuga, M., Sato, C. and Sakai, H. Stimulation of
the phosphorylation of cytoskeletal 350-kDa and 300-kDa proteins by
insulin-like growth factor-I, platelet-derived growth factor and phorbol ester
in rat 3Y1 cells. Cell Struct. Funct. 13, 417-423 (1988).
1987
Kadowaki,
T., Koyasu, S., Nishida, E., Tobe, K., Izumi, T., Takaku, F., Sakai, H.,
Yahara, I. and Kasuga, M. Tyrosine phosphorylation of common and specific sets
of cellular proteins rapidly induced by insulin, insulin-like growth factor I,
and epidermal growth factor in an intact cell. J. Biol. Chem. 262,
7342-7350 (1987).
Nishida,
E., Hoshi, M., Miyata, Y., Sakai, H., Kadowaki, T., Kasuga, M., Saijo, S.,
Ogawara, H. and Akiyama, T. Tyrosine phosphorylation by the epidermal growth
factor receptor kinase induces functional alterations in microtubule-associated
protein 2. J. Biol. Chem. 262, 16200-16204 (1987).
Nishida,
E., Iida, K., Yonezawa, N., Koyasu, S., Yahara, I. and Sakai, H. Cofilin is a
component of intranuclear and cytoplasmic actin rods induced in cultured cells.
Proc. Natl. Acad. Sci. U. S. A. 84, 5262-5266 (1987).
1986
Akiyama,
T., Nishida, E., Ishida, J., Saji, N., Ogawara, H., Hoshi, M., Miyata, Y. and
Sakai, H. Purified protein kinase C phosphorylates microtubule-associated protein
2. J. Biol. Chem. 261, 15648-15651 (1986).
Kadowaki,
T., Koyasu, S., Nishida, E., Sakai, H., Takaku, F., Yahara, I. and Kasuga, M.
Insulin-like growth factors, insulin, and epidermal growth factor cause rapid
cytoskeletal reorganization in KB cells. Clarification of the roles of type I
insulin-like growth factor receptors and insulin receptors. J. Biol. Chem.
261, 16141-16147 (1986).
Akiyama,
T., Kadowaki, T., Nishida, E., Kadooka, T., Ogawara, H., Fukami, Y., Sakai, H.,
Takaku, F. and Kasuga, M. Substrate specificities of tyrosine-specific protein
kinases toward cytoskeletal proteins in vitro. J. Biol. Chem. 261,
14797-14803 (1986).
Nishida,
E., Koyasu, S., Sakai, H. and Yahara, I. Calmodulin-regulated binding of the
90-kDa heat shock protein to actin filaments. J. Biol. Chem. 261,
16033-16036 (1986).
Koyasu,
S., Nishida, E., Kadowaki, T., Matsuzaki, F., Iida, K., Harada, F., Kasuga, M.,
Sakai, H. and Yahara, I. Two mammalian heat shock proteins, HSP90 and HSP100,
are actin-binding proteins. Proc. Natl. Acad. Sci. U. S. A. 83,
8054-8058 (1986).
1985
Yonezawa,
N., Nishida, E. and Sakai, H. pH control of actin polymerization by cofilin. J.
Biol. Chem. 260, 14410-14412 (1985).
Nishida,
E. Opposite effects of cofilin and profilin from porcine brain on rate of
exchange of actin-bound adenosine 5'-triphosphate. Biochemistry 24,
1160-1164 (1985).
Nishida, E., Muneyuki, E., Maekawa, S., Ohta, Y. and
Sakai, H. An actin-depolymerizing protein (destrin) from porcine kidney. Its
action on F-actin containing or lacking tropomyosin. Biochemistry 24,
6624-6630 (1985).
1984
Nishida,
E., Maekawa, S. and Sakai, H. Cofilin, a protein in porcine brain that binds to
actin filaments and inhibits their interactions with myosin and tropomyosin. Biochemistry
23, 5307-5313 (1984).