Laboratory of Molecular and Cellular Immunology

Professor

NODA, Takeshi
t-noda -at- infront.kyoto-u.ac.jp

Main theme

Virus infections, such as SARS CoV2, influenza A epidemic, Ebola hemorrhagic fever, Middle East respiratory syndrom, Zika virus infection are important diseases and outbreaks of newly emerging viruses are serious problems for modern society. Higher animals, including humans, are genetically equipped with mechanisms, collectively known as innate immunity, to counteract viral infections. During the course of replication, many viruses generate double-stranded (ds)RNA, which is virtually absent in normal cells and likely serves as a “foreign molecule” in cells. An RNA helicase, RIG-I, functions as a sensor for viral dsRNA. The purpose of our project is to clarify the molecular mechanism underlying the antiviral innate immunity regulated by RIG-I, and to develop new diagnostic and therapeutic means for viral infections.

 

■Recent Publications

Takeuchi, F. et. al. (2019) Screening for inhibitor of episomal DNA identified dicumarol as a hepatitis B virus inhibitor. PLOS ONE. doi:10.1371/journal.pone.0212233

Soda, N. et al. (2019) Singleton-Merten Syndrome−like Skeletal Abnormalities in Mice with Constitutively Activated MDA5. The Journal of Immunology 203, 1356. 2019  doi: 10.4049/jimmunol.1900354 July 2019

Hajake, T. et. al. (2019) Broad and systemic immune-modulating capacity of plant-derived dsRNA International Immunology, Vol. 31, No. 12, pp. 811–821 2019. doi:10.1093/intimm/dxz054

Abe, H. et. al. (2020) Priming Phosphorylation of TANK-Binding Kinase 1 by IkB Kinase b Is Essential in Toll-Like Receptor 3/4 Signaling. Molecular and Cellular Biology 40, 2020 doi.org/10.1128/MCB.00509-19.

Duic, I. et al. (2020) Viral RNA recognition by LGP2 and MDA5, and activation of signaling through step-by-step conformational changes. Nucleic Acids Research, 2020 1 doi: 10.1093/nar/gkaa935

Abu Tayeh, A. et al. (2020) Psoriasis-like skin disorder in transgenic mice expressing a RIG-I Singleton–Merten syndrome variant. International Immunology 2020  https://doi.org/10.1093/intimm/dxaa071

Onizawa, H. et. al. (2020) Aicardi–Goutières syndrome-like encephalitis in mutant mice with constitutively active MDA5. International Immunology 2020 https://doi.org/10.1093/intimm/dxaa073

Khalil, J. et. al. (2021) The Nonstructural Protein NSs of Severe Fever with Thrombocytopenia Syndrome Virus Causes a Cytokine Storm through the Hyperactivation of NF-κB. Molecular and Cellular Biology 2021 Volume 41 Issue 3 e00542-20

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