Laboratory of Cell Regulation and Molecular Network


SUGITA, Masahiko
msugita -at-

Assistant Professor

MORITA, Daisuke
dmorita -at-

MIZUTANI, Tatsuaki
mizutani -at-

Main theme

Full attention of this laboratory has been directed to previously unappreciated aspects of the acquired immunity that we call “lipid immunity” . Unlike conventional MHC molecules that present protein-derived peptide antigens, molecules of the human group 1 CD1 family (CD1a, CD1b, CD1c) mediate presentation of “lipid” antigens to specific T lymphocytes. In addition, we have recently identified a novel lineage of antigen-presenting molecules, termed LP1, capable of mediating presentation of “lipopeptide” antigens. By taking cell biological, immunological and lipid chemical approaches, this laboratory wishes to establish a molecular and cellular basis for lipid immunity and determine how CD1 and LP1 have been evolved to function critically in host defense. An important extension of this research is a challenge for developing a new type of lipid-based vaccines against cancer and microbial infection.

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Laboratory of Cell Regulation and Molecular Network Keyword

immunology  host defense, biological defense  lipid biochemistry  lipid immunity  cancer immunity  infectious immunity  vaccine development  tuberclosis  AIDS  transgenic mice