Virus infections, such as SARS CoV2, influenza A epidemic, Ebola hemorrhagic fever, Middle East respiratory syndrome, Zika virus infection are important diseases and outbreaks of newly emerging viruses are serious problems for modern society. Higher animals, including humans, are genetically equipped with mechanisms, collectively known as innate immunity, to counteract viral infections. During the course of replication, many viruses generate double-stranded (ds)RNA, which is virtually absent in normal cells and likely serves as a “foreign molecule” in cells. An RNA helicase, RIG-I, functions as a sensor for viral dsRNA. The purpose of our project is to clarify the molecular mechanism underlying the antiviral innate immunity regulated by RIG-I, and to develop new diagnostic and therapeutic means for viral infections.

• Innate immune response
• RIG-I
• Hepatitis B virus