講演タイトル
「Space, time, and biology: Stretching the limits of biological sensing with high-performance biomolecular probes」 ポスター🔗
講演者
Prof. Michael Z Lin（スタンフォード大学）
開催日時・場所
2025年7月1日（火） 16:00-17:00 医学部構内先端科学研究棟 1F大セミナー室
要旨
Living systems respond to external stimuli in useful ways through the generation of biochemical signals within and between cells. Thus understanding how biological systems orchestrate useful responses requires tracking and, ultimately, controlling how biochemical signals propagate in space and time. I will present efforts in my lab to expand the capabilities of optical imaging and control, using the brain as a testing ground. To track electrical signals, which process and transduce information at the millisecond level in the brain, we developed the ASAP family of fluorescent voltage indicators with high brightness, fast kinetics, wide dynamic range, and both one- and two-photon compatibility. Our latest ASAP5 and ASAP6 enable single-millivolt and single-millisecond recording at any point in a neuron or circuit. At the other end of the spatiotemporal range, we developed generalizable bioluminescent reporting methods to provide non-invasive readouts of biochemical activities over seconds to hours. Finally we will present new ideas for spatially regulating protein function in vivo for real time control of biological responses.
連絡先
統合生命科学専攻 遺伝機構学講座 細胞周期学分野
生命情報解析教育センター 【CeLiSIS】
青木 一洋（aoki.kazuhiro.6v@kyoto-u.ac.jp）
