Laboratory of Plasma Membrane and Nuclear Signaling

Associate Professor

YOSHIMURA, Shigehiro
yoshimura -at- lif.kyoto-u.ac.jp

Assistant Professor

KUMETA, Masahiro
kumeta -at- lif.kyoto-u.ac.jp

Main theme

Our laboratory studies dynamic properties of cellular proteins and membrane in cellular environments by using a variety of techniques in biochemistry, cellular biology and biophysical approaches. We are also interested in how those dynamics of cellular architectures are related to diseases. Specific research topics include:

  1. Cytoskeletal dynamics in cell motility and metastasis: intracellular dynamics of actin cytoskeleton is elucidated by our live-cell nano-imaging technique.
  2. Molecular mechanism of signal transduction: how plasma membrane and membrane -bound proteins coordinates endocytic process.
  3. Virus vs host cell at cell surface: imaging viral particle at the host plasma membrane to elucidate the mechanism of viral infection and proliferation.
  4. Proteins in molecular crowding: dynamic assembly and disassembly of proteins and nucleic acids in cellular environments.
  5. How do cells feel force?: elucidating molecular mechanism of mechano-sensing and -responses by combining various biophysical approaches

 

Web Site

 

 

yoshimura_e

 

Laboratory of Plasma Membrane and Nuclear Signaling Keyword

cell nucleus  chromosome  chromatin  nanobiology  single-molecule observation, single-molecule measurement  intracellular transport  atomic force microscopy  protein structure and dynamics  macromolecular crowding  structural simulation of biomolecules