yoshimura -at- lif.kyoto-u.ac.jp
kumeta -at- lif.kyoto-u.ac.jp
Our laboratory studies dynamic properties of cellular proteins and membrane in cellular environments by using a variety of techniques in biochemistry, cellular biology and biophysical approaches. We are also interested in how those dynamics of cellular architectures are related to diseases. Specific research topics include:
- Cytoskeletal dynamics in cell motility and metastasis: intracellular dynamics of actin cytoskeleton is elucidated by our live-cell nano-imaging technique.
- Molecular mechanism of signal transduction: how plasma membrane and membrane -bound proteins coordinates endocytic process.
- Virus vs host cell at cell surface: imaging viral particle at the host plasma membrane to elucidate the mechanism of viral infection and proliferation.
- Proteins in molecular crowding: dynamic assembly and disassembly of proteins and nucleic acids in cellular environments.
- How do cells feel force?: elucidating molecular mechanism of mechano-sensing and -responses by combining various biophysical approaches
Laboratory of Plasma Membrane and Nuclear Signaling Keyword
cell nucleus chromosome chromatin nanobiology single-molecule observation, single-molecule measurement intracellular transport atomic force microscopy protein structure and dynamics macromolecular crowding structural simulation of biomolecules