Division of Systemic Life Science

Laboratory of Cellular and Molecular Biomechanics

Research summary

Research outline

The Laboratory of Cellular and Molecular Biomechanics aims to clarify the self-organized regulatory mechanisms of diverse biological phenomena through interdisciplinary approaches encompassing mechanics, life science, and medical science. Our research topics cover developmental processes (cell differentiation, morphogenesis, and growth) as well as tissue/organ remodeling and regeneration which underlie functional adaptation to the environment. A major focus of our research is to understand how well-organized dynamics of living systems emerges from complex molecular and cellular interactions. To this end, we are integrating biomechanics and mechanobiology approaches to highlight the roles of “adaptation to mechanical environment” and “hierarchy of structure and function” in the living organisms using mathematical modeling, simulation and experiments.

  • Biomechanics of bone functional adaptation
    Bone can remodel its outer shape and inner structure to adapt to the surrounding mechanical environment. This study aims to clarify the mechanism of bone functional adaptation achieved through cooperative cellular activities.
  • Multiscale biomechanics on tissue morphogenesis
    Morphogenesis of biological tissues is orchestrated by mechanical forces at the multiscale. By combining experiments and simulations, this study aims to clarify the mechanisms of tissue morphogenesis.

Main themes

  • Functional adaptation mechanisms of bone to mechanical environment
  • Continuum mechanics-based modeling for multi-layered brain formation
  • Mechano-biochemical coupling mechanisms in osteocytic mechanotransduction
  • In silico and in vitro modeling of multicelluar tissue morphogenesis
  • DNA transcription mechanisms regulated by nano-scale chromatin dynamics


ADACHI, TaijiProfessor

adachi*infront.kyoto-u.ac.jp See faculty

MAKI, KoichiroAssistant Professor

maki*infront.kyoto-u.ac.jp See faculty
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