Division of Systemic Life Science

Laboratory of Genetics

Research summary

Research outline

Cells in multicellular organisms communicate with each other to facilitate normal development and homeostasis, thereby generating a functional and robust multicellular system. Disruption of such cell-cell communication leads to development and cancer and acceleration of aging. In our laboratory, we aim to elucidate the basic principles of cell-cell communications between adjacent cells (cell competition and cell-cell cooperation) and different tissues/organs that regulate tissue growth, organ development and wound healing to understand the mechanisms of tissue homeostasis, cancer, and aging.

Main themes

  • Mechanism of cell competition
  • Molecular basis of tumor progression and metastasis
  • Genetic basis of tissue growth and homeostasis
  • Mechanism of aging

Left:Polarity-deficient cells (green; losers) are eliminated from epithelium by wild-type cells (magenta; winners) through cell competition.
Right:Malignant tumor cells (magenta) are invading and metastasizing from the eye disc to the brain (blue) in Drosophila larva.

Member

IGAKI, TatsushiProfessor

igaki.tatsushi.4s@kyoto-u.ac.jp See faculty
information

KANDA, HiroshiAssociate Professor

kanda.hiroshi.2c@kyoto-u.ac.jp See faculty
information

ENOMOTO, MasatoAssistant Professor

enomoto.masato.3x@kyoto-u.ac.jp See faculty
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TANIGUCHI, KiichiroProgram-Specific Assistant Professor

taniguchi.kiichiro.3c@kyoto-u.ac.jp See faculty
information
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