Cells in multicellular organisms communicate with each other to facilitate normal development and homeostasis, thereby generating a functional and robust multicellular system. Disruption of such cell-cell communication leads to development and cancer and acceleration of aging. In our laboratory, we aim to elucidate the basic principles of cell-cell communications between adjacent cells (cell competition and cell-cell cooperation) and different tissues/organs that regulate tissue growth, organ development and wound healing to understand the mechanisms of tissue homeostasis, cancer, and aging.
- Mechanism of cell competition
- Molecular basis of tumor progression and metastasis
- Genetic basis of tissue growth and homeostasis
- Mechanism of aging
Left：Polarity-deficient cells (green; losers) are eliminated from epithelium by wild-type cells (magenta; winners) through cell competition.
Right：Malignant tumor cells (magenta) are invading and metastasizing from the eye disc to the brain (blue) in Drosophila larva.
KANDA, HiroshiAssociate Professor
ENOMOTO, MasatoAssistant Professor
TANIGUCHI, KiichiroProgram-Specific Assistant Professor
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Faculty of Pharmaceutical Campus, Graduate School of Pharmaceutical Sciences Main Bldg.