Research summary
Research outline
Cells in multicellular organisms communicate with each other to facilitate normal development and homeostasis, thereby generating a functional and robust multicellular system. Disruption of such cell-cell communication leads to development and cancer and acceleration of aging. In our laboratory, we aim to elucidate the basic principles of cell-cell communications between adjacent cells (cell competition and cell-cell cooperation) and different tissues/organs that regulate tissue growth, organ development and wound healing to understand the mechanisms of tissue homeostasis, cancer, and aging.
Main themes
- Mechanism of cell competition
- Molecular basis of tumor progression and metastasis
- Genetic basis of tissue growth and homeostasis
- Mechanism of aging
Left：Polarity-deficient cells (green; losers) are eliminated from epithelium by wild-type cells (magenta; winners) through cell competition.
Right：Malignant tumor cells (magenta) are invading and metastasizing from the eye disc to the brain (blue) in Drosophila larva.
Member
|
IGAKI, TatsushiProfessor |
igaki.tatsushi.4s*kyoto-u.ac.jp See faculty information |
|---|---|
|
KANDA, HiroshiAssociate Professor |
kanda.hiroshi.2c*kyoto-u.ac.jp See faculty information |
|
ENOMOTO, MasatoAssistant Professor |
enomoto.masato.3x*kyoto-u.ac.jp See faculty information |
|
TANIGUCHI, KiichiroProgram-Specific Senior Lecturer |
taniguchi.kiichiro.3c*kyoto-u.ac.jp See faculty information |
|
NAGATA, RinaAssistant Professor |
nagata.rina.5f*kyoto-u.ac.jp See faculty information |
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Access
Faculty of Pharmaceutical Campus, Graduate School of Pharmaceutical Sciences Main Bldg.