We are trying to unravel underlying mechanisms of adaptations to nutrient balances using Drosophila species. We are also taking interspecies approaches to understand contributions of symbiotic microorganisms to animal growth and reproductive manipulation (“male killing”). By using Drosophila somatosensory neurons, we are dissecting operating principles of neuronal circuits that evoke selective behavioral outputs in response to thermal or mechanical nociceptive stimuli. We are also interested in how genomic information and cells cooperatively build up the entire body of an organism, and trying to understand common principles of epithelial morphogenesis beyond hierarchies of genome, cells and tissues. To conduct these studies, we make full use of molecular, optogenetic, and physiological approaches, imaging, single-cell analysis and multi-omics.