watanabe.naoki.4v -at- kyoto-u.ac.jp
yamashiro.sawako.5c -at- kyoto-u.ac.jp
miyamoto.akitoshi.2c -at- kyoto-u.ac.jp
Our laboratory aims at bridging the gap between molecular activities and cell physiology in life systems. We are trying to visualize signal transduction and cell structure remodeling processes directly in living cells by fluorescence single-molecule microscopy. We have also recently invented new super-resolution microscopy called IRIS, which achieves ultra-high density labeling of multiple targets in a single specimen. By direct viewing using these advanced optical techniques, our laboratory elucidates the mechanism and the dynamics of pathophysiological cell signaling.
Laboratory of Single-Molecule Cell Biology Keyword
fluorescent single-molecule imaging cell movement cell mechanosense signal transduction actin polymerization formin family single-molecule fluorescence polarization superresolution microscopy molecular target drug kinase inhibitor cancer quantitative biology dynamic equilibrium intracellular biochemistry real-time cell physiology