Laboratory of Single-Molecule Cell Biology


watanabe.naoki.4v -at-


yamashiro.sawako.5c -at-

Assistant Professor

MIYAMOTO, Akitoshi
miyamoto.akitoshi.2c -at-

Main theme

Our laboratory aims at bridging the gap between molecular activities and cell physiology in life systems. We are trying to visualize signal transduction and cell structure remodeling processes directly in living cells by fluorescence single-molecule microscopy. We have also recently invented new super-resolution microscopy called IRIS, which achieves ultra-high density labeling of multiple targets in a single specimen. By direct viewing using these advanced optical techniques, our laboratory elucidates the mechanism and the dynamics of pathophysiological cell signaling.

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Laboratory of Single-Molecule Cell Biology Keyword

fluorescent single-molecule imaging  cell movement  cell mechanosense  signal transduction  actin polymerization  formin family  single-molecule fluorescence polarization   superresolution microscopy  molecular target drug  kinase inhibitor  cancer  quantitative biology  dynamic equilibrium  intracellular biochemistry  real-time cell physiology