Laboratory of Bioimaging and Cell Signaling

Professor

MATSUDA, Michiyuki
matsudam -at- lif.kyoto-u.ac.jp

Associate Professor

TERAI, Kenta
terai.kenta.5m -at- kyoto-u.ac.jp

Assistant Professor

SATO, Shinya
sato.shinya.7e -at- lif.kyoto-u.ac.jp

Program-Specific Assistant Professor

HINO,Naoya
hino.naoya.3a -at- kyoto-u.ac.jp

Main theme

Our research has been focused on the visualization of activities of various kinases and G proteins in living cells using biosensors based on the principle of the Förster resonance energy transfer (FRET). Our most recent study created FRET-based optogenetic tools which enables molecular activity control at single-cell resolution. These sensors and optogenetic tools will lead us to ‘talk’ with live cells under microscope to facilitate deeper understandings of the biological systems. Multiphoton microscopy of various tissues and organs of mice expressing our biosensor will reveal relationship between signal transduction and cellular behavior in physiological and pathological conditions.

Research objects

  • Development of fluorescent/luminescent biosensors to visualize signal transduction in living cells.
  • Development of optogenetics tools to control signal transduction.
  • Intercellular/intracellular signaling in living cells and living mice.
  • Analysis of intercellular communication mediated by mechanical force.
  • Multiphoton live imaging of molecular activities in the neural retina.

Web site

 

 

Laboratory of Bioimaging and Cell Signaling Keyword

cancer  intracellular signal transduction  bioimaging  fluorescent biosensor  systems biology  quantitative analysis  intercellular signal transduction  inflammation  drug discovery  pathology