matsudam -at- lif.kyoto-u.ac.jp
terai.kenta.5m -at- kyoto-u.ac.jp
sato.shinya.7e -at- lif.kyoto-u.ac.jp
We are visualizing the growth signal transduction cascades in living cells by using biosensors based on the principle of Foerster resonance energy transfer (FRET). These FRET videos are used to characterize the property of each signaling molecule. We are also developing transgenic mice expressing FRET biosensors to observe the signaling status in living mice with two-photon excitation microscopes. We also study development and plasticity of nervous system by using in vivo imaging of mouse brain.
Laboratory of Bioimaging and Cell Signaling Keyword
cancer intracellular signal transduction bioimaging fluorescent biosensor systems biology quantitative analysis intercellular signal transduction inflammation drug discovery pathology