Research Results

Laboratory of Immunobiology

Associate Professor

TAKAHARA, Kazuhiko
ktakahar -at-

Main theme

Our interest is the induction and control of immunity. We focus on dendritic cells (DCs), which are a primary antigen-presenting cell in the immune system. Our current major topics include the control of DC functions using several types of glycolipids, resulting in both immune activation and suppression. We are also interested in functions of lectin molecules expressed on DCs/macrophages that recognize polysaccharides on pathogenic agents. The study includes analyses of interaction between polysaccharides and lectins, and subsequent cellular and systemic responses in co-operation with TLR signaling. In this study, we found that certain lectin-polysaccharide interaction induced immune suppressive environment, ameliorating excessive and lethal inflammation. By these studies, we would like to develop new methods to control immune system.

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Laboratory of Immunobiology Keyword

immune response  self/non-self recognition  cell differentiation  dendritic cell  macrophage  lymphocyte  cytokine  mouse  inflamatory response  regulation of immune response  animal model of disease  microorganism  sugar chain  lecti