Laboratory of Immunobiology
ktakahar -at- zoo.zool.kyoto-u.ac.jp
Our interest is the induction and control of immunity. We focus on dendritic cells (DCs), which are a primary antigen-presenting cell in the immune system. Our current major topics include the control of DC functions using several types of glycolipids, resulting in both immune activation and suppression. We are also interested in functions of lectin molecules expressed on DCs/macrophages that recognize polysaccharides on pathogenic agents. The study includes analyses of interaction between polysaccharides and lectins, and subsequent cellular and systemic responses in co-operation with TLR signaling. In this study, we found that certain lectin-polysaccharide interaction induced immune suppressive environment, ameliorating excessive and lethal inflammation. By these studies, we would like to develop new methods to control immune system.
Laboratory of Immunobiology Keyword
immune response self/non-self recognition cell differentiation dendritic cell macrophage lymphocyte cytokine mouse inflamatory response regulation of immune response animal model of disease microorganism sugar chain lecti