Laboratory of Cell Division and Differentiation

Professor

TOYOSHIMA, Fumiko
ftoyoshi -at- infront.kyoto-u.ac.jp

Assistant Professor

ODA, Yukako
ykoda -at- infront.kyoto-u.ac.jp

ISHIBASHI, Riki
ishibashi.riki.7z -at- kyoto-u.ac.jp

Main theme

How adult tissue stem cells adapt to physiological changes is a fundamental question in stem cell biology. Balance between self-renewal and differentiation of stem cells via symmetric/asymmetric cell division is essential for steady state homeostasis. Biased stem cell self-renewal or differentiation leads to changes in tissue organization and in organ size. Our group focuses on the mechanisms of symmetric/asymmetric stem cell division, stem cell differentiation, and cell lineage-commitment in tissues metabolism and regeneration. We further research on the stem cell regulation in response to the physiological changes of the body, including pregnancy, obesity and aging.

Research subjects:

  1. Symmetric and asymmetric stem cell division in tissue homeostasis
  2. Maternal tissue stem cell dynamics during pregnancy
  3. Obesity- and age-related stem cell degeneration


 

Web site

 

 

Laboratory of Cell Division and Differentiation Keyword

cell division and differentiation  symmetric and asymmetric cell division  stem cells  epidermal tissue differentiation  maternal stem cell regulation