Laboratory of Cancer Cell Biology


HARADA, Hiroshi
harada.hiroshi.5e -at-

Associate Professor

jkobayashi -at-

Program-Specific Assistant Professor

kobayashi.minoru.4m -at-

Main theme

Cells maintain their function and morphology by exploiting a suitable adaptive response system to diverse and complex tissue microenvironments. Several lines of evidence have suggested that hypoxic, acidic and nutrients-depleted microenvironments exist in solid tumors and induce malignant phenotypes and chemo/radioresistance of cancer cells (Figure 1). We aim at elucidating molecular mechanisms responsible for cellular adaptive responses to the tumor-specific microenvironments and malignant progression of cancer cells (Figure 2).

  • Cellular adaptive responses to diverse and complex tissue microenvironments
  • Molecular mechanisms underlying malignant progression and radioresistance of cancer cells
  • Regulatory mechanisms of carbohydrate metabolic pathway


Figure 1:Hypoxic tumor cells (green) distant from blood vessels (blue) are resistant to radiation-induced DNA damage (red).

Microsoft PowerPoint - 図2.pptx

Figure 2:HIF-1-mediated gene networks responsible for both adaptive responses to hypoxia and malignant progression of cancer cells.

Web site

Laboratory of Cancer Cell Biology Keyword

Cancer  Regulation of Gene Expression  Adaptive Response to Tissue Microenvironments  Signal Transduction  Imaging  Proliferation  Metabolism