Laboratory of Biochemical Cell Dynamics

Professor

SUZUKI, Jun
suzuki.jun.6x -at- kyoto-u.ac.jp

Main theme

In principle, we identify specific genes involved in the biological phenomenon with our interests. The main approaches are as follows: Expression cloning using cDNA library, functional screening using sgRNA library in a CRISPR/Cas9 system, biochemical approach in combination with mass spectrometry. By establishing the robust experimental systems, we try to understand the biological phenomenon with interests. Currently, we are interested in the biological phenomenon called phospholipid scrambling that regulates blood coagulation, engulfment of dead cells, cell fusion, cancer progression, regulation of brain/bone/muscle functions and so on. In spite of its importance in various biological systems, much is unknown about how phospholipid scrambling is regulated. We are going to uncover the mechanisms of lipid scrambling.

Research Topic

  • Identification of novel scramblases on plasma membranes
  • Identification of novel scramblases on intracellular membranes
  • Identification of regulators or subunits in scramblases
  • Involvement of scramblases on synaptic engulfment
  • Understanding how diseases occur by scramblase deficiency
  • Screening the chemical substances regulating the scramblases
  • Exploring the new phenomenon discovered in the above projects

 

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