kengaku -at- icems.kyoto-u.ac.jp
Neurons in the mammalian brain are orderly arranged in cortices and nuclei for integration into specific neural circuits. During development, neurons directionally migrate from the birthplace to their destination within the cortex, and then arborize well-patterned dendrites and axons to contact with their specific synaptic counterparts. The major goal of our research is to clarity the mechanisms of cortical lamination and functional wiring of neurons in the brain. We seek to identify the molecular signals regulating neuronal migration and dendrite patterning. We also aim to develop imaging techniques for real-time observation of molecular and cellular dynamics of neuronal migration and dendrite patterning to discover novel phenomena and rules in neuronal motility in the developing brain.