Laboratory of Single-Molecule Cell Biology


watanabe.naoki.4v -at-


yamashiro.sawako.5c -at-

Assistant Professor

MIYAMOTO, Akitoshi
miyamoto.akitoshi.2c -at-

Main theme

Our laboratory aims at bridging the gap between molecular activities and cell physiology by visualizing signal transduction and cell structure remodeling processes with live-cell fluorescence single-molecule (eSIMS) microscopy. We have also invented new super-resolution microscopy called IRIS, which achieves ultra-high density (= high-fidelity) labeling of multiple targets in a single specimen. By real-time and high-resolution monitoring of cell structure and adhesion molecules using these advanced optical techniques, our laboratory unveils mechanisms and dynamics of pathophysiological cell signaling and body structure remodeling.

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Laboratory of Single-Molecule Cell Biology Keyword

fluorescent single-molecule imaging  cell movement  cell mechanosense  signal transduction  actin polymerization  formin family  single-molecule fluorescence polarization   superresolution microscopy  molecular target drug  kinase inhibitor  cancer  quantitative biology  dynamic equilibrium  intracellular biochemistry  real-time cell physiology