Laboratory of Single-Molecule Cell Biology

Professor

WATANABE, Naoki
watanabe.naoki.4v -at- kyoto-u.ac.jp

Lecturer

YAMASHIRO, Sawako
yamashiro.sawako.5c -at- kyoto-u.ac.jp

Assistant Professor

MIYAMOTO, Akitoshi
miyamoto.akitoshi.2c -at- kyoto-u.ac.jp

Main theme

Our laboratory aims at bridging the gap between molecular activities and cell physiology by visualizing signal transduction and cell structure remodeling processes with live-cell fluorescence single-molecule (eSIMS) microscopy. We have also invented new super-resolution microscopy called IRIS, which achieves ultra-high density (= high-fidelity) labeling of multiple targets in a single specimen. By real-time and high-resolution monitoring of cell structure and adhesion molecules using these advanced optical techniques, our laboratory unveils mechanisms and dynamics of pathophysiological cell signaling and body structure remodeling.

Web site

 

 

Laboratory of Single-Molecule Cell Biology Keyword

fluorescent single-molecule imaging  cell movement  cell mechanosense  signal transduction  actin polymerization  formin family  single-molecule fluorescence polarization   superresolution microscopy  molecular target drug  kinase inhibitor  cancer  quantitative biology  dynamic equilibrium  intracellular biochemistry  real-time cell physiology