watanabe.naoki.4v -at- kyoto-u.ac.jp
yamashiro.sawako.5c -at- kyoto-u.ac.jp
miyamoto.akitoshi.2c -at- kyoto-u.ac.jp
Our laboratory aims at bridging the gap between molecular activities and cell physiology by visualizing signal transduction and cell structure remodeling processes with live-cell fluorescence single-molecule (eSIMS) microscopy. We have also invented new super-resolution microscopy called IRIS, which achieves ultra-high density (= high-fidelity) labeling of multiple targets in a single specimen. By real-time and high-resolution monitoring of cell structure and adhesion molecules using these advanced optical techniques, our laboratory unveils mechanisms and dynamics of pathophysiological cell signaling and body structure remodeling.
Laboratory of Single-Molecule Cell Biology Keyword
fluorescent single-molecule imaging cell movement cell mechanosense signal transduction actin polymerization formin family single-molecule fluorescence polarization superresolution microscopy molecular target drug kinase inhibitor cancer quantitative biology dynamic equilibrium intracellular biochemistry real-time cell physiology