watanabe.naoki.4v -at- kyoto-u.ac.jp
yamashiro.sawako.5c -at- kyoto-u.ac.jp
miyamoto.akitoshi.2c -at- kyoto-u.ac.jp
Our laboratory aims at bridging the gap between molecular activities and cell physiology by visualizing signal transduction and cell structure remodeling processes with live-cell fluorescence single-molecule (eSIMS) microscopy. We also invented super-resolution microscopy called IRIS, which achieves ultra-high density (= high-fidelity) labeling and unlimited multiplexed staining in a single specimen. By real-time and high-resolution monitoring of cell structures and adhesion/signaling molecules, our laboratory unveils real spatiotemporal dynamics of molecular mechanotransduction, pathophysiological cell signaling, body structure remodeling and actions of target-based drugs at unprecedented resolution.