matsudam -at- lif.kyoto-u.ac.jp
terai.kenta.5m -at- kyoto-u.ac.jp
sato.shinya.7e -at- lif.kyoto-u.ac.jp
Program-Specific Assistant Professor
hino.naoya.3a -at- kyoto-u.ac.jp
Our research has been focused on the visualization of activities of various kinases and G proteins in living cells using biosensors based on the principle of the Förster resonance energy transfer (FRET). Our most recent study created FRET-based optogenetic tools which enables molecular activity control at single-cell resolution. These sensors and optogenetic tools will lead us to ‘talk’ with live cells under microscope to facilitate deeper understandings of the biological systems. Multiphoton microscopy of various tissues and organs of mice expressing our biosensor will reveal relationship between signal transduction and cellular behavior in physiological and pathological conditions.
- Development of fluorescent/luminescent biosensors to visualize signal transduction in living cells.
- Development of optogenetics tools to control signal transduction.
- Intercellular/intracellular signaling in living cells and living mice.
- Analysis of intercellular communication mediated by mechanical force.
- Multiphoton live imaging of molecular activities in the neural retina.
Laboratory of Bioimaging and Cell Signaling Keyword
cancer intracellular signal transduction bioimaging fluorescent biosensor systems biology quantitative analysis intercellular signal transduction inflammation drug discovery pathology