ktakahar -at- zoo.zool.kyoto-u.ac.jp
Our interest is the induction and control of immunity. We focus on dendritic cells (DC), which are a primary antigen-presenting cell in the immune system. We are especially interested in functions of lectin molecules expressed on DC and its relative, macrophage, that recognize polysaccharides on pathogenic agents. The study includes analyses of interaction between polysaccharides and lectins, and subsequent cellular and systemic responses in co-operation with TLR signaling. In this study, we found that certain lectin-polysaccharide interaction induced immune suppressive environment, ameliorating excessive and lethal inflammation. By these studies, we would like to develop new methods to control immune system.