Laboratory of Cellular and Molecular Biomechanics

Professor

ADACHI, Taiji
adachi -at- infront.kyoto-u.ac.jp

Assistant Professor

KAMEO, Yoshitaka
kameo -at- infront.kyoto-u.ac.jp

Main theme

Our group aims to clarify the mechanisms by which cells sense mechanical stimuli and regulate their activities in stem cell differentiation, tissue/organ morphogenesis, and functional adaptation. To better understand how these dynamical processes are mechano-regulated through complex hierarchical structure-function relationships, we are bridging spatial and temporal scales ranging from microscopic (molecular and cellular level) phenomena to macroscopic (tissue level) behaviors. Based on multiscale biomechanics integrating biomechanics and mechanobiology researches, we combine modeling and simulation with experiments to elucidate mechano-biochemical couplings in living system dynamics.

  1. Biomechanics and mechanobiology studies of stem cell differentiation, morphogenesis, and remodeling in tissue development and growth.
  2. Understanding the mechanisms of tissue development and growth emerging from multicellular dynamics.
  3. Clarifying the mechanisms of tissue functional adaptation in a mechanical environment by remodeling.
  4. Elucidation of mechano-biochemical coupling mechanisms in mechanosensory cells.
  5. Understanding mechanical behaviors of DNA in cell nucleus and the impacts on gene transcription.

 

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