Professor

HARADA, Hiroshi
harada.hiroshi.5e -at- kyoto-u.ac.jp

Program-Specific Assistant Professor

KOBAYASHI, Minoru
kobayashi.minoru.4m -at- kyoto-u.ac.jp

Main theme

Cells maintain their function and morphology by exploiting a suitable adaptive response system to diverse and complex tissue microenvironments. Several lines of evidence have suggested that hypoxic, acidic and nutrients-depleted microenvironments exist in solid tumors and induce malignant phenotypes and chemo/radioresistance of cancer cells (Figure 1). We aim at elucidating molecular mechanisms responsible for cellular adaptive responses to the tumor-specific microenvironments and malignant progression of cancer cells (Figure 2).

• Cellular adaptive responses to tumor microenvironments, e.g. hypoxia
• Molecular mechanisms underlying malignant progression and chemo/radioresistance of cancer cells
• Regulatory mechanisms of carbohydrate metabolic pathway

Figure 1：Hypoxic tumor cells (green) distant from blood vessels (blue) are resistant to radiation-induced DNA damage (red).

Figure 2：HIF-1-mediated gene networks responsible for both adaptive responses to hypoxia and malignant progression of cancer cells.

Web site

Laboratory of Cancer Cell Biology Keyword

Cancer　　Regulation of Gene Expression　　Adaptive Response to Tissue Microenvironments　　Signal Transduction　　Imaging　　Proliferation　　Metabolism