harada.hiroshi.5e -at- kyoto-u.ac.jp
Program-Specific Assistant Professor
kobayashi.minoru.4m -at- kyoto-u.ac.jp
Cells maintain their function and morphology by exploiting a suitable adaptive response system to diverse and complex tissue microenvironments. Several lines of evidence have suggested that hypoxic, acidic and nutrients-depleted microenvironments exist in solid tumors and induce malignant phenotypes and chemo/radioresistance of cancer cells (Figure 1). We aim at elucidating molecular mechanisms responsible for cellular adaptive responses to the tumor-specific microenvironments and malignant progression of cancer cells (Figure 2).
- Cellular adaptive responses to tumor microenvironments, e.g. hypoxia
- Molecular mechanisms underlying malignant progression and chemo/radioresistance of cancer cells
- Regulatory mechanisms of carbohydrate metabolic pathway
Figure 1：Hypoxic tumor cells (green) distant from blood vessels (blue) are resistant to radiation-induced DNA damage (red).