ikura.tsuyoshi.3m -at- kyoto-u.ac.jp
The purpose of our research is to clarify the role of chromatin dynamics, which is required for the DNA metabolisms such as transcription, DNA replication, and DNA repair. In particular, we focus on the molecular mechanisms by which histone modifier complexes regulate the histone eviction as chromatin remodeling machinery upon DNA damage induced by ionizing radiation. Our goal is to understand how histone eviction activates DNA damage signaling pathways and functions as an anti-cancer signaling.
Main research topics
・Memory of genomic damage
・Cellular robustness in genomic stress response
・Solution of energy metabolism mechanism in specific cancer cell