In living organisms, the “structure and motion” of biomolecules change every moment. These molecules dynamically associate and dissociate through interactions with one another, enabling them to perform complex functions as molecular assemblies. Our research focuses on elucidating the functional mechanisms of biomolecules by analyzing their structural dynamics. We use high-speed atomic force microscopy (HS-AFM) to observe the nanoscale structures and sub-second dynamics of biomolecules. Additionally, we utilize computer simulations to predict structural dynamics across multiple spatiotemporal scales. By combining these approaches, we aim to uncover the molecular mechanisms of various biomolecules from a molecular science perspective.

• Structural Dynamics in Temperature Activation of Thermosensitive Ion Channels
  Structural Dynamics of the Temperature-Dependent Contraction of the Elastic Fiber Elastin
  Structural Changes in Voltage-Gated Sodium Channels
  Membrane Recognition Mechanism of Phospholipase A2
  Intermolecular Interactions between Ion Channels that form nanocluster and Function Cooperatively in Cells